Dark Seed (or Darkseed) is a horror graphic adventure created by Cyberdreams for PC and Amiga in 1992 (and later ported to other platforms). The game illustrations were drawn by the famous artist H. R. Giger, the maker of the design for the movie Aliens. Giger wasn't happy with the typical VGA resolution of 320x200 pixels, so he asked to use the hi-res mode with 640x350 pixels. The problem is, instead of the usual 256 colors (or 32 on the Amiga) the available colors are only 16 on the ho-res mode. All of this makes the graphical style of this game really unique.
Apart from the fantastic graphics, Dark Seed is one of the scariest games you can play on your computer. It's not easy, though, so you might want to use a walkthrough.